Another metric to note is that the latency for regional persistent disk with solid-state drives (SSD) is higher than it would be for a zonal persistent disk with SSD.
https://cloud.google.com/sql/docs/mysql/high-availability#ha-performance
A, B, C. replicas and HA will help in improving read latency only. Cloud SQL enables customers to implement horizontal scaling of read-only workloads using read replicas. It might degrade the write latency.
D. Spanner satisfies the requirement without sacrificing availability
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