B answer confirmed
https://www.cisco.com/c/en/us/td/docs/security/esa/esa12-0/user_guide/b_ESA_Admin_Guide_12_0/b_ESA_Admin_Guide_12_0_chapter_011011.html
The certificate-based SMTP authentication profile allows the appliance to authenticate an SMTP connection over TLS using a client certificate. When creating the profile, you select the Certificate Authentication LDAP query to use for verifying the certificate. You can also specify whether the appliance falls back to the SMTP AUTH command to authenticate the user if a client certificate is not available.
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