Segregating Incoming and Outgoing Mail
You can segregate incoming and outgoing email traffic over separate listeners and on separate IP addresses. You can use Internet Protocol version 4 (IPv4) and version 6 (IPv6) addresses. However, the System Setup Wizard on the email gateway supports initial configuration of the following configurations:
2 separate listeners on 2 logical IPv4 and 2 IPv6 addresses configured on separate physical interfaces
segregates incoming and outgoing traffic
you can assign an IPv4 and an IPv6 address to each listener
1 listener on 1 logical IPv4 address configured on one physical interface
combines both incoming and outgoing traffic
you can assign both an IPv4 and an IPv6 address to the listener
https://www.cisco.com/c/en/us/td/docs/security/esa/esa14-0/user_guide/b_ESA_Admin_Guide_14-0/b_ESA_Admin_Guide_12_1_chapter_010.html
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