*C. Keeping process variability within limits.**
**Explanation:**
- **Six Sigma** focuses on reducing process variability and defects by using statistical methods to achieve near-perfect quality (3.4 defects per million opportunities). Its core goal is to maintain tight control over processes to ensure consistency and predictability.
- **Lean manufacturing** primarily aims to eliminate waste (e.g., overproduction, waiting, and unnecessary inventory) and improve efficiency in processes.
- **Just-in-time (JIT)** focuses on reducing inventory levels and producing only what is needed, when it is needed, to minimize waste and costs.
While **designing quality into products and processes (D)** is a shared goal across all three methodologies, the **emphasis on controlling process variability** is a defining characteristic of Six Sigma. This makes **C** the most distinguishing factor.
A key concept distinguishing six sigma from lean manufacturing and just-in-time (JIT) concepts is:
A. reducing waste.
B. eliminating inventories.
C. keeping process variability within limits.
D. designing quality into products and processes.
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